Available Technologies - Search Results
| Title: | Method Of Inhibiting The Transport Of L-glutamate |
|---|---|
| UC Case No: | 1989-036-2-ott |
| Categories: |
Veterinary:
Animal Health
Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Drug Production and Design, Drug Targets and Screening Tools, Protein Folding and Interactions, Research Tools |
| Background: | L-Glutamate is one of the most abundant excitatory neurotransmitters in the mammalian brain and, as such, is responsible for many synaptic transmissions in the central nervous system. Yet, while other neurotransmitters are degraded rapidly to terminate the transmitter signal, L-glutamate is removed from the synaptic cleft by high affinity transport. Furthermore, little is known about the conformational requirements of substrate binding to this transport system. |
| Technology: | Researchers at the University of California, Irvine, have developed novel compounds that are potent and selective inhibitors of the high affinity transport of L-glutamate. These compounds will be used to investigate the mechanism of the transport system and will be evaluated for their therapeutic efficacy for the treatment of various neurological disorders such as ischemia, hypoglycemia, epilepsy, Huntington's disease, and Alzheimer's disease. |
| Contact: |
Maria Tkachuk, Licensing Associate Office of Technology Alliances University of California, Irvine 380 University Tower Irvine, CA 92697-7700 Phone: (949) 824-2288 FAX: (949) 824-2899 Email: mtkachuk@uci.edu |
| Patent Status: | U.S. Patent No. 5,942,537 |
| UCI School: | School of Physical Sciences |
| Department: | Chemistry |
