Available Technologies - Search Results
| Title: | Pharmacological Role of Prolactin-Releasing Peptide in Controlling Absence Seizures |
|---|---|
| UC Case No: | 1999-206-2-ott |
| Categories: |
Pharmaceuticals:
Central Nervous System Disorders
Biotechnology: Drug Targets and Screening Tools |
| Technology: | University of California, Irvine researchers have found that prolactin releasing peptide (PrRP) modulates the activity of the brain's reticular thalamic nucleus (RTN). The RTN is characterized by prominent PrRP receptor expression which is critical in the regulation of the non-convulsive type of epilepsy called absence seizures. Injection of PrRP into animals significantly decreased spike-and-wave discharges (SWD) which is characteristic of absence seizures. |
| Application: | These results indicate that PrRP modulates reticular thalamic function and that activation of its receptor provides a new therapeutic target for absence seizures and other disorders dependent on PrRP receptors. |
| Contact: |
Ronnie Hanecak, Ph.D., Associate Vice Chancellor (Interim) Office of Technology Alliances University of California, Irvine 380 University Tower Irvine, CA 92697-7700 Phone: (949) 824-7186 FAX: (949) 824-2899 Email: rhanecak@uci.edu |
| Patent Status: | Pending |
| UCI School: | College of Medicine |
| Department: | Pharmacology |
