Available Technologies - Search Results
| Title: | Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase |
|---|---|
| UC Case No: | 2002-460-2-ott |
| Categories: |
Biotechnology:
Drug Targets and Screening Tools
|
| Technology: | University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes with unique structural characteristics. An overproduction of NO has been linked to several diseases, conditions and addictions, including: ischemic injury and other brain damage after stroke, migraine headache, Alzheimer's Disease, colitis, tissue damage, inflammation, septic shock and rheumatoid arthritis. |
| Application: | This discovery provides for drug discovery and design protocols for isoform drugs that target NOS isoforms and reduce NO production. |
| Contact: |
Ronnie Hanecak, Ph.D., Associate Vice Chancellor (Interim) Office of Technology Alliances University of California, Irvine 380 University Tower Irvine, CA 92697-7700 Phone: (949) 824-7186 FAX: (949) 824-2899 Email: rhanecak@uci.edu |
| Patent Status: | U.S. Patent No. 7,056,945 |
| UCI School: | School of Biological Sciences |
| Department: | Molecular Biology & Biochemistry |
